It might, or you may end up chasing your tail. The main problem I've found with "wipe-on" finishes is the tendency to leave "wipe marks", much like "brush marks" in other manually applied finishes. Sanding those out just isn't any fun, especially with polyurethane because it doesn't like to be worked after the fact. Some polys will flow out better than others, though. When I used to shoot catalyzed poly or enamels on cars, it used to go on looking like most spray finishes - all orange-peeled - but if you waited 5 minutes the stuff would flow out and look like wet glass. Just magical.
Unfortunately, for a variety of reasons most DIY-types aren't set up to shoot that, so the wipe-on solution is a good one to get you poly on your part, which can be a Good Thing.
I've done some necks with wipe-on poly, and I've found you have to be a little ambitious about the amount applied, but at the same time cautious not to over-apply lest you sag or run it, since it doesn't set up fast like lacquer does. If you can find the right application rate, it'll flow out without sagging or running on you and save you a lotta work later. Part orientation helps - you want the finish to lay there, not hang there, otherwise mean ol' Mr. Gravity will pull sags/runs that'll be tough to get out later.
Check what you're using and make sure you're following recommendations for temperature during application.