Since the circuitry that turns on the tuner when you pull on the volume knob also mutes the output, I very much doubt that would work. But I don't think the N-Tune is something you want or need in every guitar (or bass) you own. It's great for times when you take your guitar and amp, and nothing else. Not even a stomp tuner. You probably have just one guitar you'd take in such a case, and that's the one you put the N-Tune in.