There are tons of good pickups these days for every budget. I have Suhrs in my strat now and there are very good. They replaced Kinmans which were good too, I just had them and wanted to try and see how they sound. I have played several Warmoth strats with Van Zandts, excellent tone from all.
Your amp/cab/speaker are important too. I bought an alnico speaker a few days after I had installed the Suhrs and the tone just got better in clean and breakup sounds. Bigger difference than changing pickups so you need to consider everything in your signal chain.