Yes, the area 58 works perfect with the humbuckers- neither the jazz or pearly gates are high output, balances great. and the 58 is clear as a bell, great sounding with some tube breakup od. but the 58 has that single coil tab, so I dont think it would fit in the emg single coil space unless you routed it. Also, the 58 sounds amazing when used with the full humbucker jazz, or with the jazz split (this is an almost acoustic clean tone- one of my newest favorite tones, nice and smooth, but emotive and expressive), i have mine wired up to have both choices. the 58 clean (in the mid position) is really bright, a bit bright for me to use totally clean, but with a bit of tube od, it sounds very vintage strat.