Along the lines of Tim's post, I am no expert on history and nationalism in Iran by any means, but from what I do know, there is really interesting precedent for protest in Iran. Filmmakers have been producing politically-charged movies for decades, both before and after the Islamic revolution. Those political angles are prohibited, but filmmakers have bypassed those laws through subtle (and sometimes not-so-subtle) use of symbolism and the like. When the films were shown, the are 'safe' and 'tame' enough to remain legal - usually - but still get the point across.
If anyone thinks this isn't totally boring, check out the director Mohsen Makhmalbaf.
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As for the Koran... nowhere is the United States ever mentioned (obviously); said hatred comes from certain folks' interpretations of certain verses. Other Muslims interpret these verses differently - just like discussions over interpretation of Biblical passages in the US.
I'm with you Superlizard to the extent that I take issue with hatred and violence, especially when justified by supposed religious law. I feel the same way about Jihadists as I do about members of the Christian right in the US who encourage hate, moral superiority, strict separatism.
My point is, if blame must be placed, place blame on the individuals, the actors. Not the Koran (nor the Bible, but that is a whole different conversation!)