I have Area 58s in the neck and middle, and a 61 in the bridge. For jazz/blues, they are beyond perfect. When I have the mid control at about 5 and the middle and neck in series with the Albert King setting on my amp, the sound is beyond amazing. No hum whatsoever on any setting. They're also good for classic rock. Just don't expect to get any good pinch harmonics or fat tone. But if you're getting single coils, you probably aren't looking for that in the first place. For jazz/blues/classic rock and similar genres, I'd recommend them in a heartbeat.
If you're getting them, let me recommend the Voodoo Tone Monster Strat harness from http://www.guitar-mod.com . That's what I have the pickups in, and I have such tone versatility, and it sounds so, so amazingly clean. I've played my share of Strats, and this beats it all. I also have an alder body, so you probably will have a similar experience. Get 'em.