The choice of 15's and 10's will be important.
This is where considerable experience would help. You can not only get different frequency response, but also varying degrees of efficiency (loudness per watt). Couple that with - how will they respond together in the same cabinet?
FWIW, I have a '62 Princeton that rather dark toned, and it sounded GREAT when played together with a Fender Blues Jr. The Princeton had a dark 10, the BJ had a rather bright 12, and the amps were different of course, but they could be dialed in GREAT, especially when the BJ was a little raspy edged on the OD and the Princeton was still clean.