To play guitar in a bar band that covers the pantheon, there are three tones that go a long way.
1) The Strat neck pickup into a relatively clean tube head and good clean speakers, non-buzzy - call it the "Little Wing" tone, SRV and Eric Johnson learned it there anyway. It has to be a single coil Strat PU in the neck, tapped humbuckers won't do it - but you can put a Strat pickup into a tele... :evil4:
2) A good strong bridge humbucker, driving some power tubes more than preamp tubes, and again into clean hi-fi speakers like JBL, Altec Lansing, Black Widows etc. - call it the Duane Allman/early Santana tone;
3) a tone with more preamp drive, into Celestion 30's (or Webers), blatty and nasty, Stones/AC/DC.
It was way back in the '80s when Steve Morse and Eric Johnson began touring with two amps on all the time, a roaring Marshall into Celestions for midrange overdrive and a Fender(ish) amp into JBLs to pick up cleaner highs and lows. It's really hard to get that third, nasty tone without the exploding speakers, but you can approximate at least the EQ at with something like a Fulltone Fulldrive 2, tube screamer(ish) or something similar, a box that boosts midrange and cuts bass.
Of the three tones, this last one is least useful to me musically, and I don't want to carry two amps, so I just depend on a pedal. The one thing you can't do, in my experience, is get a loud clean tone out of a cheap rock 'n' roll speaker like the Celestion 30's, Vegas or Webers. Eminence makes both dirty and clean speakers, even Celestion makes some "60s" and "75s" that can take some juice.
ALL of these tones have some turned-down analogue... the problem with really good hi-fi speakers is that they're rated at 350 watts and a dinky little 18 watt amp into a JBL D120 will barely flap it. God, the troubles we have....