Brian May is a whole 'nother thing, and is awesome too! There are a few tones that make it into that top league, and then it's down to opinion.
Back in the day when it was really happening real-time, Ed's most famous body was from Charvel and the neck from Boogie Bodies. At least according to his interview in Guitar Player during that era. That's why I went straight for the Boogie Bodies stuff and built the red one shown on my posts.
It's right on the money except the body is koa. The Duncan Distortion is even screwed down solid to the body! Lynn Ellsworth himself came to my house & sold me 2 necks & a body. One neck went onto a very early Kramer Pacer long before Ed endorsed Kramer. Premonition? I just needed two nearly identical guitars, and I already had the Kramer. Lynn & I walked around my dad's yard and looked at trees & talked about wood. That's a day I'll never forget. He also said that Ed would love the stripes I did on my Kramer! I could have cried.
The other neck and the koa body became my Red One, which has been my favorite for decades. Everyone who plays it says it's the best thing ever. Sometimes you just stumble upon that magical chunk of wood, and this is it. Lynn was pissed when he heard I painted it red!
And after working on it for a long time, I have the tone. Vintage Marshall, blah-secret-stuff-blah-blah. I haven't wanted or needed any different amp stuff in decades. It's a great place to be! Now I'm into 7s and don't even play The Red One anymore. But I could never part with it...
