I got my hands on a Mesa Mark V, used, pristine, for just a hair more than that 5150 is new. Three channels, three settings for each, sorta like 9 amps in one. It'll run at 10, 45, or 90 watts. But it also has a Variac power setting which is a sorta "brown-out" feature. So running 10 watts +Variac makes driven sounds more manageable for home use.
One little trick for crunchy/gainy sounds is to run the gain high, the preamp level as low as possible, but the master volume as high as possible. This tends to shift the focus of low-volume performance from the preamp section to the power section, whose growl is a lot prettier.
That being said, when wound up, it will really pump. I live in an apartment, so I have to hike it over to a buddy's place to give it a workout. But with the approach above, I get some really sweet sounds at home, and have yet to have a neighbor knock on my door (but I have really good neighbors)
The Mesa amps are known for their hi-gain sound. But that's not all they do. The Mark V is wildly adjustable, but like Bagman said, its adjustability is a little daunting for those who are used to Vol/Treb/Bass. A little twist here or there can change its character dramatically. I got better at it when I stopped worrying about what the knobs were set at, and just turned 'em 'till they sounded good.
I like bluesy and rocky stuff, not metal. But with the right settings, I can get any of the 6 higher-gain channels to be bluesy, and each a little different. You just have to know how to "play" it. Like Bagman said, it's an instrument.
When I first got it, a fella I know would lend me a different overdrive pedal each week, for me to try out. I tried a half-dozen. And I ended up keeping.... none of them. Because I'd run the pedal through the clean channel, and find that I could get the same sound straight from the amp, just up a channel or two, and tweaked right. Run the pedal through the medium -gain channels, same story. I haven't used an overdrive pedal in months.
An attenuator would be nice though, to get the output stage warmer. I know that I saved somewhere a link to a "poor man's DIY attenuator", with the intention to give it a try when I had time (ha ha). I'll try to dig that up.