With enough switches you can do most anything. If you want to put two pickups in series I would recommend you combine reverse wound, reverse polarity pickups to minimize noise. This is likely neck + mid, or mid + bridge assuming you have a RWRP pickup set.
On the first couple strats I built I had a mess of toggle switches offering almost every conceivable combination of pickups in parallel, series and out of phase. I found that in live play situations the complexity was impractical. With enough fiddling when recording you could get some good sounds but after several years of ruminating have come around to feel that minor variations on the standard 5 position switch and stock wiring get you most of the tones worth having. I also fooled with blend pots on various guitars but have returned to more simple control schemes after a lot of experimentation.
If you want to explore do not forget to consider 250K pots with push/pull switches and/or the incredibly useful Super Switch (4 pole, 5 way) from StewMac or elsewhere.
Note that the concentric pot arrangements and push/pull pots sometimes run afoul of a whammy bar if you are using one.
Am just finishing a Tele with coil tapped neck and bridge pickups with a 5 way Super Switch offering hot neck, twangy neck, parallel, twangy bridge and hot bridge positions. Works really great although not exactly traditional Tele.
Have fun,
RM