Just to be clear - humbucker coils are not out of phase from each other, neither are normal strat single coils. The reason that two strat pups together sound "quacky" and two tele pickups don't, is because the signals from the two strat pickups are so similar that 'phase cancellation' happens in certain frequencies. This does reduce the overall volume a bit, but not nearly as much as actual "out of phase" pickups. The tele pickups produce quite different sounds, so fewer freqs are phase cancelled. To experiment, take your strat and wire the + and - of the middle pickup backwards and see what kind of sound you get in 2 and 4 when it actually is "out of phase".