For speaker cable you can use heave gauge wire that is used in power cords, like the orange extension cable. Heavy gauge stuff, not the 18 gauge of the cheap-o-rama stuff. The two wire 16-14 gauge is fine, the 18 stuff is usually cheap stuff that is prone to problems. It is black (hot) tip and white (sleeve) in the US. Harder to find with all of the grounded stuff, but most hardware stores carry it. Also get a crazy color, so you can always yell at the guys trying to steal it from you at the club that the (blank) color cords are yours.
Instrument cord is shielded, as mentioned. Shield, or braid, goes to the sleeve, and conductor is the tip. Do not use this for speakers, as mentioned, it has much less for power capability, and you can change the impedance load on your amp, potentially frying the output transformer. Don't argue this one, just don't do it.
Patrick