There's a semi-famous player named Jimmy Herring who's main guitar is a Fender Custom shop Strat with two Seymour Duncan humbuckers, and he says it sounds mostly like a Strat, just fuller. On his solo album at least, his tone is almost exactly like the mid-rangey-but-Fender harmonica-esque 25.5" bolt-on humbucking tone that Steve Morse uses, although Morse has many other choices too. Herring spent a lot of time playing with Butch Trucks and Warren Haynes in various Dead/Allman incarnations, so he's spent some time on tone....
http://www.youtube.com/watch?v=jsNdCZSTqdo&feature=related