For tuners, look at the Planet Waves locking tuners, I have them on all my guitars, and you can find them cheap on ebay.
The chambered body will not only tolerate a chambered body, but will thrive on them. My tele is a chambered body.
As to the neck, I love the big fat wide necks. 1 and 3/4 is great, with the boat style. It is a matter of personal taste. My hands have gotten stretched out over the years and I find the skinny necks, especially the 1 5/8's, impossible.