Depends on the pickup. On a typical Tele with a "standard" Tele pickup, I suspect it would sound the same as any typical Tele - like you were chewing on tinfoil while somebody jammed an icepick in your ear.
But, it doesn't have to be that way.
Put a humbucker down there, or any of dozens of aftermarket single coils, and it'll be fine.
But, that's just me. I hate typical Teles with "standard" pickups.