I have a chambered Strat, no F hole, and I love it. It weighs less, certainly, but there is also a vibe to it that is hard to explain. When I was young, and first learning to play guitar, sometimes I would be playing my electric guitar without plugging in, and I noticed that if I touched the end of the headstock to a desk, or table or something, there would be this slight amplification of the vibrating strings. The chambered Strat is like that on it's own. PLugged into a raging, distorted amp, you probably can hear no difference, but playing clean I definitely think there is more "sing" to the tone. I think it was worth it, and I would do it again.